Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2589945 | NeuroToxicology | 2010 | 4 Pages |
Abstract
We present four cases of fragile X premutation carriers with early neurological symptoms, including symptoms consistent with multiple sclerosis (MS) and fragile X-associated tremor/ataxia syndrome (FXTAS). Each patient had significant exposure to one or more environmental neurotoxicants that have documented neurotoxicity (i.e. hexachlorocyclopentadiene or C56, Agent Orange, and 2,4- or 2,6-toluene diisocyanate and dichlormate). We hypothesize that premutation carriers are a vulnerable group to neurotoxins because elevated mRNA in the premutation can lead to early cell death and brain disease, leading to neuropsychiatric and neurological symptoms consistent with FXTAS.
Keywords
Related Topics
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Environmental Science
Health, Toxicology and Mutagenesis
Authors
Ripon Paul, Isaac N. Pessah, Louise Gane, Michele Ono, Paul J. Hagerman, James A. Brunberg, Flora Tassone, James A. Bourgeois, Patrick E. Adams, Danh V. Nguyen, Randi Hagerman,