Article ID Journal Published Year Pages File Type
2590287 NeuroToxicology 2008 9 Pages PDF
Abstract

Oxidative stress is implicated in the pathogenesis of central nervous system damage in neurodegenerative diseases as well as in normal aging. Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases caused by both environmental and inherited factors. DJ-1 mutations were recently identified in familial PD. The aim of this study was to elucidate the effects of the neurotoxins rotenone and 6-hydroxydopamine that lead to intracellul

Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
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