Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2591418 | Neurotoxicology and Teratology | 2013 | 6 Pages |
Abstract
⺠Prenatal terbutaline exposure is associated with increased incidence of ASD. ⺠Developing rats given terbutaline showed deficient peripheral noradrenergic development. ⺠Vulnerability depended on the concentration of β2-adrenoceptors in the target organs. ⺠Effects were not shared by stimulants acting at β1- or α1-adrenoceptors. ⺠Noradrenergic deficits may contribute to autonomic dysfunction in ASD or after terbutaline given for preterm labor.
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Authors
Theodore A. Slotkin, Frederic J. Seidler,