| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2591781 | Neurotoxicology and Teratology | 2010 | 11 Pages |
Abstract
The relationship between the blood lead concentration and cognitive function in children and adults with different VDR genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16Â years old, performance on the digit span and arithmetic tests as a function of the blood lead concentration varied by VDR rs2239185 and VDR rs731236 genotypes. Decreases in performance occurred in some genotypes, but not in others. In adults 20 to 59Â years old, performance on the symbol-digit substitution test as a function of the blood lead concentration varied by VDR rs2239185-rs731236 haplotype. In the 12 to 16Â year old children and adults 60 or more years old, the relationship between the serum homocysteine and blood lead concentrations varied by VDR genotype. The mean blood lead concentrations of the children and adults did not vary by VDR genotype.
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Authors
Edward F. Jr., Mary Ann Butler, Man-huei Chang, Tiebin Liu, Ajay Yesupriya, Nicole Dowling, Mary Lou Lindegren, for the CDC/NCI NHANES III Genomics Working Group for the CDC/NCI NHANES III Genomics Working Group,