| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2592344 | Regulatory Toxicology and Pharmacology | 2012 | 10 Pages |
Recommendations to increase the consumption of the long-chain omega-3 fatty acids are challenged by the global problem of declining fish stocks. Non-traditional and more sustainable sources of the long-chain omega-3 fatty acids are needed. Squid (Todarodes pacificus) represents a uniquely sustainable source of these fatty acids. A 13-week oral toxicity study was conducted in male and female Sprague-Dawley rats administered either 0, 250, 500, or 1000 μl/kg body weight (bw)/day of a refined squid oil. All of the rats survived through to the end of the study. All of the rats grew normally and had normal clinical and ophthalmic observations. No signs of toxicity were evident from clinical chemistry, hematology, and urinalysis data measured. No abnormal findings attributable to exposure to purified squid oil were observed following the necropsy of male and female rats and the histopathological examination of the organs. The no-observed-adverse-effect level for refined squid oil was determined to be 1000 μl/kg bw/day, the highest dose tested.
► Squid (Todarodes pacificus) represents a uniquely sustainable source of the long-chain omega-3 fatty acids. ► A refined squid oil was tested in a 13-week oral toxicity study conducted in male and female Sprague-Dawley rats. ► Doses tested were 0, 250, 500, or 1000 μl/kg body weight (bw)/day. ► The NOAEL was 1000 μl/kg bw/day, the highest dose tested. ► No signs of toxicity and no abnormal findings attributable to exposure to purified squid oil were observed.
