Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2593527 | Reproductive Toxicology | 2014 | 8 Pages |
Abstract
This study investigated potential cumulative effects of multiple pregnancy and multigenerational exposure to dietary ZEA (0, 0.8, 4, or 20Â ppm) on female puberty and reproduction in C57BL/6J mice. Multiple pregnancies did not significantly affect litter size or offspring puberty. Significant effects were observed in 20Â ppm ZEA-treated females: advanced puberty onset in F0, F1, and F2 generations; decreased implantation rate, pregnancy rate, and litter size, and increased pregnancy gap and gestation period in F1 and F2 generations; and reduced fertility index in F2 generation. F3 females from 0 and 20Â ppm groups were split into 0 or 20Â ppm ZEA diets at weaning, with advanced puberty onset seen in 0-20 and 20-20 groups and decreased implantation rate observed in 20-20 group. In summary, 20Â ppm dietary ZEA advanced puberty onset without obvious cumulative effect and impaired fertility with multigenerational cumulative effect, which could be partially alleviated upon exposure cessation.
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Authors
Fei Zhao, Rong Li, Shuo Xiao, Honglu Diao, Ahmed E. El Zowalaty, Xiaoqin Ye,