| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2593570 | Reproductive Toxicology | 2013 | 10 Pages |
Crl:CD(SD)rats were given 3-cyanopyridine by gavage at 0, 5, 30 or 180 mg/kg/day. Males were dosed for 42 days beginning 14 days before mating, and females for 40–53 days beginning 14 days before mating to day 3 of lactation, including throughout the mating and gestation periods. General toxicity, mainly liver damage, was observed in males at ≥30 mg/kg/day and in females at ≥5 mg/kg/day. Sertoli cell vacuolation was observed at 180 mg/kg/day, and spermatocyte damages were observed at ≥30 mg/kg/day. Effects on estrous cycles, corpora lutea and implantations, and unsuccessfully mated females, despite additional mating, were observed at 180 mg/kg/day. Delayed initiation of delivery, dystocia, and deaths or moribundities of pregnant females were observed at 180 mg/kg/day, and only two pregnant rats delivered live pups at that dose. The NOAEL for reproductive/developmental toxicity was concluded to be 30 mg/kg/day.
► 3-Cyanopyridine was evaluated for reproductive and developmental toxicity in rats. ► Histopathology findings in male reproductive organs were observed at 180 mg/kg/day. ► Toxicological effects on female reproduction were observed at 180 mg/kg/day. ► At 180 mg/kg/day, abnormal deliveries were found and only two females had live pups. ► NOAEL for reproductive/developmental toxicity was concluded to be 30 mg/kg/day.
