| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2593646 | Reproductive Toxicology | 2012 | 13 Pages |
Perfluorooctanesulfonate (PFOS) has been found in biological samples in wildlife and humans. The geometric mean half-life of serum elimination of PFOS in humans has been estimated to be 4.8 years (95% CI, 4.0–5.8). A series of studies was undertaken to establish pharmacokinetic parameters for PFOS in rats, mice, and monkeys after single oral and/or IV administration of K+PFOS. Animals were followed for up to 23 weeks, and pharmacokinetic parameters were determined by WinNonlin® software. Rats and mice appeared to be more effective at eliminating PFOS than monkeys. The serum elimination half-lives in the rodent species were on the order of 1–2 months; whereas, in monkeys, the serum elimination half lives approximated 4 months. Collectively, these studies provide valuable insight for human health risk assessment regarding the potential for accumulation of body burden in humans on repeated exposure to PFOS and PFOS-generating materials.
► Perfluorooctanesulfonate is found in biological samples from wildlife and humans. ► Pharmacokinetic parameters for PFOS in rats, mice, and monkeys were evaluated. ► Rats and mice appeared to be more effective at eliminating PFOS than monkeys. ► Half-lives in rodents and monkeys approximated 1–2 and 4 months, respectively.
