Albendazole causes stage-dependent developmental toxicity and is deactivated by a mammalian metabolization system in a modified zebrafish embryotoxicity test

Article ID	Journal	Published Year	Pages	File Type
2593750	Reproductive Toxicology	2012	12 Pages	PDF

Abstract

âº The zebrafish embryo toxicity test with an external metabolization system was further developed and additional testing time points with extended exposure durations were included. âº The anthelmintic drug albendazole caused stage dependent toxic effects in zebrafish embryos. âº Albendazole was efficiently metabolized and deactivated by the external metabolization system.

Keywords

β-naphtoflavone DPF NADPH β-NF hpf ABZ DMSO Albendazole albendazole sulfone albendazole sulfoxide Malformations days post fertilization MAS Dimethyl sulfoxide hours post fertilization Developmental toxicity Phenobarbital Metabolism reduced β-nicotinamide adenine dinucleotide phosphate Zebrafish