| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2593757 | Reproductive Toxicology | 2012 | 7 Pages |
In the past three decades, magnetic resonance imaging (MRI) has been increasingly used in obstetrics to aid diagnostics of maternal and fetal conditions and has generally been considered a safe imaging method. However, the development of higher-performance systems employing, for example, stronger fields to improve the technique's diagnostic potential, necessitates on-going safety evaluation. Rodent studies provide an excellent opportunity to investigate not only acute but also long-term effects of magnetic field exposure in a systematic manner, and a behavioral analysis might help to uncover subtler effects which might result from magnetic field exposure of the vulnerable developing brain. We conducted a comprehensive investigation of emotional and cognitive behavior in adult mice which had been repeatedly exposed to a 7 Tesla static magnetic field in utero. Using well-validated tests, we did not observe any adverse behavioral alterations regarding emotional behavior as well as spatial and emotional learning.
► We study behavior of adult mice prenatally exposed to a 7 T static magnetic field. ► We do not observe adverse effects on emotional and cognitive behavior. ► Our data support the notion of magnetic resonance imaging as a safe imaging method.
