| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2594026 | Reproductive Toxicology | 2011 | 9 Pages |
Abstract
⺠Fetal death, fetal growth restriction and fetal malformation were observed in TCDD-exposed rats. ⺠TCDD stimulated the expression of Igf2 in both fetal liver and BRL-3A cells. ⺠We identified a C/EBPβ responsive element on the Igf2 P3-promoter. ⺠TCDD may induce Igf2 gene expression through the transactivation of C/EBPβ. ⺠This pathway may be linked to the developmental effects of TCDD in rats.
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Authors
Jun Wang, Xiaoliang Liu, Tingting Li, Caixia Liu, Yanyan Zhao,