Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2594360 | Reproductive Toxicology | 2011 | 11 Pages |
Abstract
Proposals of such decision criteria for substances with potential endocrine disrupting properties in human health risk assessment were developed by the German Federal Institute for Risk Assessment (BfR) and discussed at an expert workshop in November 2009. Under consideration of the requirements laid down within the new plant protection product legislation and the scientific discussions during the workshop, a conceptual framework on evaluation of substances for endocrine disrupting properties in a regulatory context is presented in this paper. Central aspects of the framework include assessment of adversity of effects, establishment of a mode/mechanism of action in animals, considerations concerning the relevance of effects to humans and two options for a regulatory decision.
Keywords
MOAOECDMRLBFREECEFSAIPCsTTCPPPNOAELDNTCMREDCGHSGlobally harmonised systemEPAADIThreshold of toxicological concernEnvironmental Protection AgencyEuropean UnionEuropean Economic CommunityEndocrine disruptionEuropean Food Safety AuthorityRisk assessmentDESDITInternational Programme on Chemical SafetyRegistration, Evaluation, Authorisation and Restriction of ChemicalsEuropean CommunityMargin of exposureMaximum residue levelAcceptable daily intakeDiethylstilbestrolREACHWorld Health OrganizationNGOnon-governmental organisationOrganisation for Economic Co-operation and DevelopmentDevelopmental immunotoxicityendocrine disrupting chemicalDevelopmental neurotoxicityRepeated exposureplant protection productNo observed adverse effect levelMOEWHO
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Authors
P. Marx-Stoelting, R. Pfeil, R. Solecki, B. Ulbrich, K. Grote, V. Ritz, U. Banasiak, B. Heinrich-Hirsch, T. Moeller, I. Chahoud, K.I. Hirsch-Ernst,