| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2594457 | Reproductive Toxicology | 2008 | 5 Pages |
ObjectiveTo assess the safety of cetirizine during pregnancy.Study designA prospective observational cohort study with data of the Berlin teratology information center from 1992 until 2006. Pregnancy outcome was compared between a cohort of pregnant women exposed to cetirizine during the first trimester (n = 196) and a control group not exposed to potential teratogens (n = 1686).ResultsMajor birth defects were not more common in the study group than in the control group (OR 1.07; CI 0.21–3.59). We also compared the crude rate of spontaneous abortions (OR 0.97; CI 0.54–1.65), of preterm deliveries (OR 0.76; CI 0.35–1.5), and the birth weight of term newborns (p = 0.13).ConclusionsThis prospective observational study on cetirizine in pregnancy suggests that the use of cetirizine is relatively safe during the first trimester.
