Developmental neuropathology in DNT-studies—A sensitive tool for the detection and characterization of developmental neurotoxicants

Developmental neurotoxicity (DNT-) studies are the first reproduction toxicity studies for which an extended histopathological examination of developing structures is required by the current EPA and OECD guidelines. The morphological screening includes a macroscopic evaluation of the brain and nervous tissue, brain weight parameters, gross morphometry of the brain, neurohistological examinations and a quantitative analysis of major brain areas. This review is intended to give an overview about the needs according to guideline requirements, practical approaches for a successful developmental neuropathology and its preconditions and does include examples of background data on the value and functional meaning of morphological data. A selection of experimental data from literature is also presented in the light of their contribution for the understanding of important, neurodevelopmental disorders in humans.