| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2596694 | Toxicology | 2009 | 6 Pages |
Abstract
Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury.
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Authors
Malgorzata Debiak, Kai Kehe, Alexander Bürkle,