| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2599600 | Toxicology Letters | 2012 | 4 Pages |
Abstract
⺠We investigated the kinetic interactions of a homologous series of oximes with native and cyclosarin-inhibited human AChE. ⺠The length of the oxime alkyl side chain was correlated with an increased affinity towards native AChE. ⺠The effect of the alkyl side chain on the affinity and reactivity towards phosphonylated AChE was moderate. ⺠In comparison to the reference oxime HI-6 all tested oximes had a lower reactivating potency.
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Authors
Franz Worek, Anne Bierwisch, Timo Wille, Marianne Koller, Horst Thiermann,