Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2601810 | Toxicology Letters | 2006 | 5 Pages |
Abstract
Genotoxic effects of acrylamide are supposed to result from oxidative biotransformation to glycidamide. After incubation of rat liver slices with acrylamide we detected free glycidamide using a liquid chromatography tandem mass spectrometric method. Glycidamide formation was diminished in the presence of the cytochrome P450 2E1 inhibitor diallyl sulfide (DAS), which is a specific ingredient of garlic. This may be relevant to human health since the suggested carcinogenic risk of dietary acrylamide may be reduced by concomitant intake of garlic.
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Authors
Dirk Taubert, Reinhild Glöckner, Dieter Müller, Edgar Schömig,