Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2602236 | Toxicology Letters | 2007 | 5 Pages |
Abstract
Diethylstilbestrol (DES) causes DNA adducts resulting in breast cancer, whereas diallyl sulfide (DAS) inhibits cancer formation. We hypothesize that DAS induces the expression of nucleotide excision repair genes. To test this hypothesis, female ACI rats were treated for 4 days with corn oil, DES, DAS, and DAS/DES (50 mg/kg). The expression of P53, Gadd45a, PCNA, and DNA polymerase delta was analyzed by real-time PCR. DES decreased the expression of P53, Gadd45a and PCNA. DAS and DAS/DES increased the expression of all four genes. These results suggest that DAS enhances the ability of breast tissue to repair DNA damage thus preventing cancer.
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Mario Green, Oneil Newell, Ayoola Aboyade-Cole, Selina Darling-Reed, Ronald D. Thomas,