| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2602615 | Toxicology in Vitro | 2011 | 6 Pages |
Abstract
⺠Myeloperoxidase is able to convert 5OH-TBZ to a cytotoxic, reactive, intermediate. ⺠The reactive intermediate was equally toxic to various cell types: NRK-52E, H9C2, and rat primary proximal tubule cells. ⺠The reactive intermediate induces cell death through necrosis rather than apoptosis. ⺠The bioactivation of 5OH-TBZ can be prevented by the MPO inhibitor rutin. ⺠The reactive intermediate is the only significantly toxic thiabendazole product in vitro, and may cause toxicities in vivo.
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Authors
Joseph D. Jamieson, Evan B. Smith, Deepak K. Dalvie, Gregory J. Stevens, Gina M. Yanochko,