Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2603223 | Toxicology in Vitro | 2010 | 4 Pages |
Abstract
Toxicity of the environmental carcinogen chromate is known to involve sulfur starvation and also error-prone mRNA translation. Here we reconcile those facts using the yeast model. We demonstrate that: (i) cysteine and methionine starvation mimic Cr-induced translation errors, (ii) genetic suppression of S starvation suppresses Cr-induced mistranslation, and (iii) mistranslation requires cysteine and methionine biosynthesis. Therefore, Cr-induced S starvation is the cause of mRNA mistranslation. This establishes a single, novel pathway mediating the toxicity of chromate.
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Authors
Sara L. Holland, Ekalabya Ghosh, Simon V. Avery,