Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2603676 | Toxicology in Vitro | 2006 | 5 Pages |
Abstract
The effect of lead exposure on non-adrenergic non-cholinergic (NANC) relaxations in rat gastric fundus was evaluated in this work. Wistar rats were divided into four groups: The control group received tap water and the three other received 0.008% of lead acetate in their drinking water for 15, 30 and 120 days. NANC relaxations induced by electrical field stimulation (0.5-8 Hz, 1 ms, 60 V) of gastric fundus strips was inhibited in all groups treated with lead. The strips from groups, control and 120 days of lead treatment (LEAD 120), were incubated with l-NOARG (100 μM). The presence of this blocker did not produce any additional inhibition. Sodium nitroprusside (10â10-10â6 M) and 8-Br-GMPc (3 Ã 10â8-3 Ã 10â4 M) produced dose-dependent relaxations in strips of both groups control and LEAD 120, however, in the LEAD 120, the potencies were significantly reduced from 7.32 ± 0.05 to 6.40 ± 0.09 (n = 5) and 4.26 ± 0.06 to 3.69 ± 0.05 (n = 5), respectively. Our data suggest that the chronic exposure to lead inhibits NANC relaxations probably by modulating NO release from NANC nerves and/or by interacting with intracellular transducer mechanisms in rat gastric fundus.
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Authors
M.R.V. Santos, M. Marchioro, A.R. Antoniolli,