Conséquences systémiques des brûlures étendues

Extensive burns induce many organ dysfunctions. The essential pathophysiologic event is an intense and prolonged systemic inflammatory response syndrome (SIRS). This evidence is based largely on experimental and clinical studies. Modern fluid resuscitation therapies are based on recent knowledge in the mechanisms of burn shock. Post-burn vascular changes with increased capillary permeability and inflammatory mediators lead to the shock. The toxic components of fire smoke explain the complex pulmonary injuries related to inhalation. Different strategies for attenuating post-burn hypermetabolism state have been recently developed. Goals in acute management of burns are to maintain vital organ function and to obtain early skin coverage.