Article ID Journal Published Year Pages File Type
2613211 Réanimation 2010 4 Pages PDF
Abstract
Recombinant human activated protein C (APC) has been demonstrated to reduce the mortality rate of adult patients with severe sepsis. This effect was thought to be related to its anticoagulant and anti-inflammatory processes in severe sepsis. Indeed, data from the Prowess study demonstrated that the use of APC was associated with a quicker reduction in cardiovascular failure. Recent animal data have suggested that APC may improve both vascular and myocardial dysfunction and vascular reactivity to catecholamines during endotoxin and/or septic challenges. These effects appear to be related to an attenuation of endothelial cell-leukocyte activation and to a marked reduction in inflammation and oxidative stress at both the vascular and cardiac level.
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