Sérum salé hypertonique, quoi de neuf ?

The treatment of shock states often requires fluid replacement. Hypertonic saline is an alternative to conventional solutions, isotonic crystalloids or colloids. The concept of low-volume resuscitation has grown over the last 30 years mainly in the areas of hemorrhagic shock and brain osmotherapy. More recently, hypertonic saline has been evaluated in other types of shock, of cardiogenic and septic origin. Improvement of the hemodynamic failure is due to the combination of increased preload, increased contractility and improvement of the microcirculation. Other properties such as immunomodulation or anti-edematous effects are interesting in many types of shocks. Data mainly issued from animal models argue for clinical trials in different diseases.