Les troubles graves de l'hémostase

Tissue factor and factor VII now play a major role in the modern coagulation scheme. Platelets with their activatable surface amplify the thrombin burst. Additional elements have to be taken into account. The drop in red blood cell impairs primary haemostasis and thrombin generation. Hypothermia affects platelet function and decreases the kinetics of coagulation factors. Choc and hypocalcemia also play a deleterious role. Finally, hemodilution related to volume replacement solutions will increase the impairment of coagulation, especially when these solutions, as high molecular weight starches, develop an intrinsic effect on haemostasis.