Sepsis sévère et grossesse

Severe sepsis or septic shock during pregnancy or in the post partum period are rare. Only twelve percent of maternal mortality is due to severe sepsis or septic shock. The immune status and the modifications of the cardiovascular system during pregnancy explain the relatively good tolerance of women with bacteremia or an infection. On the other hand, myocardial dysfunction, which may develop rapidly, is associated with a poor prognosis. Sepsis syndrome must be recognized soon in order to start an empirical and effective antibiotherapy based on microbiological data related to the source of the infection. Maternal and foetal tolerance to antibiotics must be considered, as well as the dose regimen in accordance with the increase of volumes of distribution. Conventional therapy for sepsis or septic shock must conform to the current guidelines.