The Crisis of IRIS: What Every Nurse Should Know About Immune Reconstitution Inflammatory Syndrome in Patients Infected with HIV

Most health care providers are aware that beginning combination antiretroviral therapy (ART) for patients infected with HIV has reduced morbidity of AIDS-related opportunistic infections and subsequently reduced HIV-related mortality. Effective ART leads to significantly reduced viral loads and increased CD4+ T cell counts, especially in the first few months after initiation. ART stimulates immune system reconstitution, thereby reducing the risk of exacerbation or acquisition of an opportunistic infection.