Article ID Journal Published Year Pages File Type
2661044 The Journal for Nurse Practitioners 2012 5 Pages PDF
Abstract

Naloxone is an opioid antagonist that competitively binds to opioid receptors and reverses all of their effects. The indication for use is respiratory depression as a result of known or suspected opioid overdose. Clinicians involved in patient care must use the drug appropriately, rather than as a diagnostic tool, such as to determine the etiology of a change in mental status. This article reviews the pharmacokinetics and pharmacodynamics of naloxone. In addition, the appropriate administration is reviewed using a case study approach.

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