Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2666013 | Journal of PeriAnesthesia Nursing | 2015 | 13 Pages |
Abstract
Epidural, spinal, regional, local, and intravenous administration of local anesthetics (LAs) is a cornerstone of anesthetic practice. LA toxicity is a grave consequence that is of great significance to anesthesia providers. Outcomes of LA toxicity range from inconvenient symptoms such as tinnitus, twitching, and hypotension to seizures; cardiovascular or respiratory collapse; and death. Lipid emulsion has emerged as a potential “magic bullet” in treating LA toxicity. This literature review provides background information and proposed mechanisms of action for LAs and lipid emulsion as well as animal experiments and a case report that speak to the effectiveness of lipid emulsion in the face of LA toxicity.
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Authors
Shawn Collins, Judy Neubrander, Zachary Vorst, Brad Sheffield,