Hyperbilirubinemia in the Late Preterm Infant

Hyperbilirubinemia is the leading cause of rehospitalization in the late preterm infant (Tomashek, Sem in Perinatology. 2006). Immaturity of the infant's gastrointestinal tract and hepatic system, along with immaturity of feeding, leads to an increased risk of hyperbilirubinemia and the need for medical attention. To better understand the risks of hyperbilirubinemia, we will explore the normal bilirubin metabolism and alterations seen in the late preterm. Because the ultimate goal of treatment of hyperbilirubinemia is the prevention of kernicterus, we will also explore the causes of kernicterus and the increased susceptibility in the late preterm.