Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2687273 | Clinical Nutrition | 2010 | 5 Pages |
Abstract
SummaryProfound metabolic changes occur in people with type 1 diabetes mellitus during insulin deprivation. These include an increase in basal energy expenditure and reduced mitochondrial function. In addition, protein metabolism is significantly affected during insulin deprivation. A greater increase in whole-body protein breakdown than protein synthesis occurs resulting in a net protein loss. During insulin deprivation the splanchnic bed has a net protein accretion which accounts for the total increase in whole-body protein synthesis while muscle is in a net catabolic state.
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Authors
Sadie L. Hebert, K. Sreekumaran Nair,