Night splinting does not increase ankle range of motion in people with Charcot-Marie-Tooth disease: A randomised, cross-over trial

QuestionWhat is the effect of wearing splints at night to stretch the plantarflexors on dorsiflexion range of motion (ROM) in people with Charcot-Marie-Tooth disease?DesignRandomised, assessor-blinded, cross-over trial.Participants14 people (1 dropout) aged 7 to 30 years with Charcot-Marie-Tooth disease Type 1A and with ≤ 15 degrees dorsiflexion range of motion (ROM).InterventionA splint holding the ankle in maximum dorsiflexion was worn nightly on one leg for 6 weeks followed by the opposite leg for the subsequent 6 weeks.Outcome measuresThe primary outcome was dorsiflexion ROM; secondary outcomes were eversion ROM, and dorsiflexion, eversion, and inversion strength, measured before and after splinting, and three months later.ResultsThere was no significant difference between the experimental and the control intervention in terms of ROM or strength. Wearing the splint at night increased dorsiflexion ROM by 1 degree (95% CI –3 to 4; p = 0.72) and eversion ROM by 1 degree (95% CI –1 to 3; p = 0.28) compared to not wearing the splint. Wearing the splint increased dorsiflexion strength by 41 N (95% CI –53 to 135; p = 0.38), reduced eversion strength by 6 N (95% CI –112 to 101; p = 0.92) and reduced inversion strength by 8 N (95% CI –110 to 95; p = 0.88) compared to not wearing the splint.ConclusionWearing night splints does not increase ankle ROM or strength in people with Charcot-Marie-Tooth disease Type 1A.