Long-term effects of the daily wear of senofilcon A silicone hydrogel contact lenses on corneal and conjunctival tissues

PurposeThe objective of the investigation was to show that, because of their overall properties, Acuvue® Oasys™ with Hydraclear® Plus brand (senofilcon A) silicone hydrogel contact lenses achieve excellent ocular tissue tolerance during long-term daily wear.MethodsThe 2-year investigation was a prospective daily wear analysis of Acuvue® Oasys™ with Hydraclear® Plus (senofilcon A) silicone hydrogel contact lenses replaced every 2 weeks and used in conjunction with a representative range of care systems.ResultsThe 2-year results compared with the subjects' baseline ocular status on entering the study revealed:•For new wearers, there was no change in the limbal zone and significant improvement in the bulbar area, both in terms of hyperemia and staining and in corneal staining.•For established contact lens wearers, there was an improvement in all 3 characteristics.ConclusionsThe quantification of the effects on the ocular tissues of 2 years of daily wear of senofilcon A, by mainly previously successful daily soft contact lens wearers, showed an excellent biocompatibility. The results support the hypothesis that senofilcon A contact lenses, when worn on a 2-week daily wear regimen, maintain excellent long-term ocular tissue tolerance.