Recurrent Strokes in Two Patients With POEMS Syndrome and Castleman’s Disease

POEMS syndrome is a disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Castleman’s disease is a rare lymphoproliferative disorder that can be present in patients with POEMS syndrome. Previous case reports have documented the association between POEMS syndrome and arterial and venous thromboses of the coronary and lower limb arteries. However, only 3 patients have ever been described with POEMS syndrome, Castleman’s disease, and stroke. Two additional patients with this combination of disorders are reported herein. We suspect that the strokes are a result of a possible intracranial vasculopathic process.