| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2713110 | The Foot | 2013 | 9 Pages |
ObjectiveTo systematically review and meta-analyse published data about the diagnostic performance of Fluorine-18-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and PET/computed tomography (PET/CT) in osteomyelitis related to diabetic foot.MethodsA comprehensive literature search of studies on 18F-FDG-PET and PET/CT in patients with diabetic foot was performed. Pooled sensitivity, specificity, positive and negative likelihood ratio (LR+ and LR−) and diagnostic odds ratio (DOR) and area under the summary ROC curve of 18F-FDG-PET and PET/CT in patients with osteomyelitis related to diabetic foot were calculated.ResultsNine studies comprising 299 patients with diabetic foot were included in the qualitative analysis (systematic review) and discussed. The quantitative analysis (meta-analysis) of four selected studies provided the following results on a per patient-based analysis: sensitivity was 74% [95% confidence interval (95%CI): 60–85%], specificity 91% (95%CI: 85–96%), LR+ 5.56 (95%CI: 2.02–15.27), LR− 0.37 (95%CI: 0.10–1.35), and DOR 16.96 (95%CI: 2.06–139.66). The area under the summary ROC curve was 0.874.ConclusionsIn patients with suspected osteomyelitis related to diabetic foot 18F-FDG-PET and PET/CT demonstrated a high specificity, being potentially useful tools if combined with other imaging methods such as MRI. Nevertheless, the literature focusing on the use of 18F-FDG-PET and PET/CT in this setting remains still limited.
