Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2724751 | Journal of Pain and Symptom Management | 2007 | 5 Pages |
Abstract
Chronic idiopathic singultus (hiccup) is a debilitating condition affecting mostly elderly males. While in the past, pharmacologic singultus treatment was mostly “trial and error,” more recently, treatment has become both more evidence based and pathophysiology guided. A combination of an acidity-reducing drug (H2-receptor blocker or proton pump inhibitor) with baclofen (gamma-amino-butyric-acid receptor type B agonist) has become the most widely used regimen. Some clinicians replace or supplement baclofen with gabapentin. We present three cases of chronic idiopathic hiccup managed with gabapentin or another alpha-2-delta ligand, pregabalin. This is the first reported use of pregabalin for this indication.
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Authors
Alexander Jatzko, Anka Stegmeier-Petroianu, Georg A. Petroianu,