| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2732111 | The Journal of Pain | 2014 | 11 Pages |
Abstract
We show that IL-10-producing monocytes/macrophages promote resolution of transient inflammatory hyperalgesia. Additionally, we show that reduced monocyte/macrophage GRK2 impairs resolution of hyperalgesia and reduces IL-10 production. We propose that low GRK2 expression and/or impaired IL-10 production by monocytes/macrophages represent peripheral biomarkers for the risk of developing chronic pain after inflammation.
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Authors
Hanneke L.D.M. Willemen, Niels Eijkelkamp, Anibal Garza Carbajal, Huijing Wang, Matthias Mack, Jitske Zijlstra, Cobi J. Heijnen, Annemieke Kavelaars,