Femmes à haut risque de cancer mammaire : vers des unités et réseaux de surveillance

High risk may be defined as either an absolute risk greater than 20 % or a relative risk greater than 4. Concerning breast and ovarian cancer, high risk patients include carriers of constitutive deleterious mutation of BRCA1 or BRACA2 genes, patients with significant family history of breast or ovarian cancer, and patients who have been diagnosed a benign breast lesion with a high risk of degeneration (atypical hyperplasia). Following up such patients relies on specific strategies. A center including a large panel of physicians involved in the various modalities for patients' management, i.e. geneticians, radiologists, gynecologists, medical oncologists, pathologists, endocrinologists, psychologists and plastic surgeons, has been created in our institution with this purpose. The collaboration of these different specialists with the referent physician of the patient allows for the definition of a patient-centered follow-up continuously updated to take into account the different periods of a woman's life, according to best practices.