Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2743516 | Anaesthesia & Intensive Care Medicine | 2008 | 4 Pages |
Abstract
Drug elimination is the irreversible removal of drug from the body. In order to discuss the process, it is necessary to understand how the body handles drugs with a description of hepatic, renal and pulmonary clearance, as well as some of the other less common routes of elimination. Knowledge of first-pass metabolism along with discussion of the various disease states affecting elimination processes will allow better prediction of pharmacokinetics in practice.
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Authors
Jonathan N. Wilkinson, Iain K. Moppett, Jonathan G. Hardman,