Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2748856 | Best Practice & Research Clinical Anaesthesiology | 2007 | 14 Pages |
Abstract
Despite the common use of red-blood-cell transfusions in clinical practice, actual beneficial effects of red blood cells have never been demonstrated. On the contrary, several studies suggest that red-blood-cell transfusions are associated with higher risks of morbidity and mortality. The effects of the duration of storage on the efficacy of red blood cells have therefore been questioned in a number of studies. Recent insights into the physiology of red blood cells – such as the role of the hypoxia-induced vasodilator-releasing function of red blood cells – is discussed in relation to the controversy surrounding the use of blood transfusions in clinical practice.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Anesthesiology and Pain Medicine
Authors
Emre Almac, Can Ince,