Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2754911 | Clinical Lymphoma Myeloma and Leukemia | 2014 | 5 Pages |
Abstract
Delta-like homologue 1 (DLK1) is an imprinted gene, that acts as a Notch pathway antagonist. It is deregulated in solid and blood cancers, conferring malignant cells a cancer stem cell-like phenotype. DLK1 is important for normal hematopoiesis and for bone marrow homeostasis, because it directly affects the differentiation of mesenchymal stem cells into the nonhematopoietic components. It is possible that the resulting abnormal biology of mesenchymal stem cells promotes leukemic blasts survival providing also a sanctuary against chemotherapeutic agents. In this review, the effects of DLK1 on mesenchymal stem cells and the bone marrow microenvironment with perspectives are discussed.
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Authors
Leonidas Benetatos, Eleftheria Hatzimichael,