Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2754989 | Clinical Lymphoma Myeloma and Leukemia | 2013 | 6 Pages |
BackgroundLenalidomide is indicated for treatment of multiple myeloma in combination with dexamethasone and as a single agent in myelodysplastic syndromes. The incidence and risk of rash has been inconsistently reported.Materials and MethodsWe conducted a systematic review and metaanalysis of the literature to determine the incidence and risk of developing rash. Relevant studies were identified from PubMed and abstracts presented at American Society of Clinical Oncology annual meetings. Incidence, relative risk, and 95% confidence intervals were calculated.ResultsTen trials were available for analysis, and the overall incidence of all-grade and high-grade rash was 27.2% and 3.6%, respectively. Lenalidomide was associated with increased risk of all-grade rash (P < .001).ConclusionFurther studies for prevention and treatment of this toxicity are needed to minimize effect on quality of life and dose intensity.