Inhibition of Thrombin During Reperfusion Improves Immediate Postischemic Myocardial Function and Modulates Apoptosis in a Porcine Model of Cardiopulmonary Bypass

Conclusions: The improved cardiac recovery in the r-hirudin group during reperfusion after cardioplegia-induced cardiac arrest was associated with significant differences in cardiomyocyte apoptosis and anti-inflammatory effects. Thus, in clinical cardiac surgery, inhibition of reperfusion- induced thrombin may offer beneficial effects by mechanisms other than direct anticoagulation.