Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2762597 | Journal of Clinical Anesthesia | 2013 | 4 Pages |
Abstract
Serotonin syndrome is gaining attention in perioperative and chronic pain settings due to the growing prevalence of multimodal therapies that increase serotonin levels and thereby heighten patient risk. A patient's genetic make-up may further increase the risk of serotonin syndrome. A case of serotonin syndrome on emergence after general anesthesia is presented. A subsequent cytochrome P4502D6 genetic test result suggested a potential alteration in metabolism. For this patient, who was taking combination antidepressant medications and receiving common perioperative medicines, additive pharmacodynamic effects converged with a pharmacogenetic predisposition, resulting in serotonin syndrome.
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Authors
Nicole C. Beatty, Wayne T. Nicholson, Loralie J. Langman, Timothy B. Curry, John H. Eisenach,