Article ID Journal Published Year Pages File Type
2762675 Journal of Clinical Anesthesia 2011 5 Pages PDF
Abstract

Study ObjectiveTo investigate whether methylene blue, given before injection of propofol, was effective in reducing the frequency and severity of pain associated with propofol injection.DesignProspective, randomized, double-blinded clinical study.SettingOperating room of a university hospital.Patients90 adult, ASA physical status 1 and 2 patients undergoing elective surgery.InterventionsPatients were randomly allocated to one of three groups of 30 patients each. Group I received 50 mg of methylene blue, Group II received 40 mg of lidocaine, and Group III, the control group, was given normal saline. All drugs were given as a 2.0 mL bolus 45 seconds before propofol administration.MeasurementsInjection pain using vocal responses, facial grimacing, arm withdrawal, tears, and questioning of the patient were noted. A 4-point scale was used for documenting pain.Main ResultsPain frequency was 90% in the saline group, whereas the frequencies were significantly lower in the lidocaine and methylene blue groups (26.7% and 40%, respectively).ConclusionsIntravenous pretreatment with methylene blue appears to be effective in reducing the pain during propofol injection.

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