Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2762856 | Journal of Clinical Anesthesia | 2012 | 4 Pages |
Abstract
Propofol is widely used for sedating critically ill adult patients because of its rapid onset and short recovery times, even after prolonged use. Propofol may be associated with a life-threatening syndrome, propofol-related infusion syndrome (PRIS), which includes cardiac failure, severe metabolic acidosis, renal failure, and rhabodomyolysis. The pathophysiology is incompletely understood. Propofol-related infusion syndrome seems to be dose-related, and it occurs generally in patients undergoing long-term (> 48 hrs) sedation at higher doses (> 4 mg/kg/hr). A case of PRIS in a patient after severe head injury is presented.
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Authors
Thorsten Annecke, Peter Conzen, Ludwig Ney,