Article ID Journal Published Year Pages File Type
2763313 Journal of Clinical Anesthesia 2011 5 Pages PDF
Abstract

Study ObjectivesTo evaluate the effects of intravenous (IV) tranexamic acid on blood loss and surgical field quality during functional endoscopic sinus surgery (FESS).DesignRandomized, double-blinded, controlled trial.SettingOperating room and postoperative recovery area of a university-affiliated hospital.Patients84 consecutive, adult, ASA physical status 1 and 2 patients undergoing FESS.InterventionsPatients were randomized to receive either IV tranexamic acid 10 mg/kg (TA group) or sterile water 0.1 mL/kg (placebo group) as a bolus dose immediately after induction of anesthesia.MeasurementsAmount of blood loss and bleeding and satisfaction scores were obtained from the surgeon.Main ResultsBlood loss in the TA group was 184 ± 64 mL and in the placebo group, 312 ± 75 mL on average (P < 0.01). The median (range) bleeding score in the TA group was significantly lower than the placebo group [2 (1-3) vs 2.5 (2-4); P < 0.0001]. The surgeon was more satisfied with the surgical field in the TA group than the placebo group [median score: 4 (3-5) vs 3 (1-5), P < 0.001].ConclusionIntravenous tranexamic acid effectively reduces bleeding and improves the surgical field during FESS.

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