Dental sedation for patients with intellectual disability: a prospective study of manual control versus Bispectral Index-guided target-controlled infusion of propofol

Study ObjectiveTo investigate the use of propofol sedation using Bispectral Index (BIS)-guided target-controlled infusion (TCI) in dental patients with intellectual disability.DesignSingle-center, prospective, randomized clinical trial.SettingAcademic outpatient clinic.Subjects40 ASA physical status 1 and 2 patients with intellectual disability.InterventionsPatients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol.MeasurementsThe required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded.Main ResultsBIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening.ConclusionPropofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.