Article ID Journal Published Year Pages File Type
2763438 Journal of Clinical Anesthesia 2009 4 Pages PDF
Abstract

Study ObjectiveTo evaluate and compare the efficacy and related side effects of alfentanil and remifentanil in preventing the withdrawal movement associated with rocuronium injection.DesignProspective, randomized, blinded, placebo-controlled clinical trial.SettingOperating room of a university hospital.Patients115 ASA physical status I and II adult patients.InterventionsPatients were randomly allocated to one of three study groups. Group C received saline, Group A received alfentanil 10 μg/kg, and Group R received remifentanil one μg/kg, each in a volume of three mL. Treatments were injected over 30 seconds, followed by thiopental sodium. At 90 seconds after the start of the study drug injection, rocuronium 0.6 mg/kg was injected over 10 seconds.MeasurementsCough, breathholding, and thoracic muscle rigidity were observed while injecting the study drug. Each patient's response to the rocuronium injection was graded on a 4-point scale in a blinded manner.Main ResultsDuring injection of the study drug, Group R showed a significantly higher frequency of cough than Group A (24% vs. 2%; P < 0.05). One Group R patient presented with apnea. Frequency of withdrawal movement in Groups A and R were significantly lower than that in Group C (6% and 0% vs. 63%; P < 0.0001) but there was no significant difference between the two groups.ConclusionWhen administered 90 seconds before rocuronium injection, alfentanil showed a comparable effect to that of remifentanil in attenuating rocuronium-associated withdrawal movement, and a lower frequency of side effects such as cough.

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