Local Anesthetics Time-Dependently Inhibit Staphylococcus aureus Phagocytosis, Oxidative Burst and CD11b Expression by Human Neutrophils

Our results indicate that in a whole blood model, time-dependent effects of local anesthetics affect key neutrophil functions necessary for bacterial elimination. However, these effects only occur at concentrations that are unlikely to be routinely attained in the clinical setting, and concern about interfering with the host defense is likely unwarranted.